With decades of experience in developing and manufacturing multiparticulate oral controlled release formulations, we provide end-to-end capabilities to support your molecule from concept to commercialization.

Our scientific team combines extensive knowledge of multiparticulate systems with innovative problem-solving to design optimal formulations that meet your target product profile and release kinetics.

We understand the complexities of multiparticulate development and have established robust processes to address challenges in formulation design, process optimization, and scale-up to ensure consistent quality from clinical trials through commercial manufacturing.

• Custom multiparticulate formulation design – pellets, beads, minitablets, granules
• Expert formulation and process design to achieve desired size distribution and potency
• Controlled release profile development – sustained, delayed, pulsatile, or targeted release
• Multiple coating options – functional polymers, enteric coatings, taste masking
• Final dosage form flexibility – capsules, sachets, or MUPS tablets
• Combinations of multiple bead populations to achieve custom release profiles
• Dissolution method development for biopharmaceutics assessment, IVIVC, and QC
• Comprehensive analytical testing and characterization

Our advanced manufacturing capabilities for multiparticulate systems include:

• Drug loading by solution-, suspension-, or powder-layering, extrusion-spheronization, direct pelletization, or minitablet compression
• Wurster or rotor processor coating for functional polymer coating (aqueous or solvent)
• Two-piece hard capsule filling (gelatin or HPMC) with pellets, granules, powders, or minitablets
• Tablet compression or small-scale sachet filling
• Scalable equipment from feasibility batches to commercial production (1 – 300 kg)

We support your multiparticulate development with rigorous quality systems and regulatory expertise to accelerate your path to market while meeting all compliance requirements.